A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis.
نویسنده
چکیده
منابع مشابه
Mechanistic studies of acid-evoked coughing in anesthetized guinea pigs.
Experiments carried out in conscious guinea pigs suggest that citric acid-evoked coughing is partly mediated by transient receptor potential vanilloid type 1 (TRPV1) receptor-dependent activation of tachykinin-containing, capsaicin-sensitive C fibers. In vitro electrophysiological analyses indicate, however, that acid also activates capsaicin-sensitive and -insensitive vagal afferent nerves by ...
متن کاملآلرژنهای هوایی در تست پوستی بیماران مبتلا به آسم، رینیت آلرژیک، اگزما و کهیر مزمن در ایران
Asthma is a common chronic inflammatory of airways especially in childhood. Clinical manifestations include coughing, wheezing and sometimes dyspnea. Allergic rhinitis (AR) is a common nasal inflammatory disease in the world. Prevalence of AR is 10-40% in different regions of the world. Clinical manifestations of allergic rhinitis are sneezing, pruritus, congestion and rhino rhea. Etiologies of...
متن کاملProstanoids and cough response to capsaicin in asthma and chronic bronchitis.
Cyclooxygenase products are released by chronic airway inflammation. Our working hypothesis for the present study was that prostanoids augment airway cough sensitivity. The effects of a cyclooxygenase inhibitor, indomethacin (100 mg.day-1 for 4 days), and a thromboxane synthesis inhibitor, OKY-046 (400 mg.day-1 for 4 days), on cough response to inhaled capsaicin were examined in eight patients ...
متن کاملRole of afferent nerves and sensory peptides in the mediation of hepatic artery buffer response.
Intrahepatic arteries are richly innervated by both adrenergic and sensory vanilloid-sensitive (capsaicin-sensitive) fibers. Stimulation of capsaicin sensitive fibers has been shown to dilate the intrahepatic vessels by both releasing sensory neuropeptides and by modulating the adrenergic tone. However the participation of capsaicin-sensitive fibers in the mediation of the hepatic artery buffer...
متن کاملCapsaicin sensitivity in patients with chronic cough– results from a cross-sectional study
BACKGROUND A subgroup of patients with chronic cough is recognised as having airway symptoms resulting exposure to chemicals and scents related to enhanced cough sensitivity to inhaled capsaicin. Sensory hyperreactivity, which has an estimated prevalence of more than 6%, is one possible explanation for the symptoms experienced by these patients. We hypothesized that a number of patients diagnos...
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عنوان ژورنال:
- Thorax
دوره 48 4 شماره
صفحات -
تاریخ انتشار 1993